T3 & t4 are highly protein-bound hormones that can be affected by numerous factors lik…
FT3, FT4, TSH
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T3 & t4 are highly protein-bound hormones that can be affected by numerous factors like illness, medications and genetic factors that influence protein binding. therefore it is useful to measure the free or unbound hormone levels which correspond to the biologically available hormone pool. The ability to quantitate circulating levels of TSH is important in evaluating thyroid function. it is especially useful in the differential diagnosis of primary (thyroid) from secondary (pituitary) and tertiary (hypothalamic) hypothyroidism. TSH assays with increased sensitivity and specificity provide a primary diagnostic tool to differentiate hyperthyroid from euthyroid patients.